Dec organizes and participates in many events throughout the year such as exhibitions, conferences and seminars. 2020 has seen the exception with the pandemic of COVID-19 where many events had to be canceled or postponed. So please feel free to benefit of the convenience to gain insight over the Internet directly on your computer.
Fill Finish - desarrollo de nuestra línea para llenado de polvo & líquido con el sistema de multi-cámara
Webinar in Spanish
Providing liquid solutions in vials or bags remains the most common way to administer injectable medications. When drugs cannot be stored in liquid form due to poor stability and limited shelf life, they are generally stored in lyophilized form and must be diluted prior to injection using a diluent.
The risk of possible contamination or error is a major concern of the healthcare industry. To overcome these problems, many pharmaceutical producers are looking for new drug delivery systems, such as double packaging, where the powder and diluent solution are stored in separate compartments.
Dec has acquired specific experience in this area and can propose customized solutions for the automatic filling of various delivery systems such as blisters, vials, bags, syringes including the concept of dual chamber systems for solids & liquids.
Topics include
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Advantages of double chamber delivery systems
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Closed process with the concept of isolators
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Modular and flexible solutions for future adaptability
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Filling methods for products with various characteristics
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Dosing speed and volumes
PTS Batchmixer® Lo último en velocidad y flexibilidad
Primer mezclador sin partes móviles o giratorias.
WEBINAR IN SPANISH
Depending on the cohesion of the materials, differences in bulk density and particle size, selecting an appropriate mixer that achieves a satisfactory balance between mixing speed and segregation can be challenging.
The patented PTS Batchmixer® allows mixing powders with different characteristics in a contained environment while reducing overall process times compared to traditional systems.
The system is particularly suitable for pharmaceutical applications where the active substances must be handled without contamination or changes in physical properties.
This webinar presents Dec's innovative technology to mix powders in a fully contained way without using rotating or moving parts and where the mixing efficiency is above average.
Topics include:
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Performance of the PTS Batchmixer®
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R&D processes and applications and pilot plants
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Process integration in existing plant
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Handling of active, toxic and/or sterile products
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Installation space compared to conventional mixers
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Cleaning & sterilization, validation
The trend towards pre-filled disposable syringes whether of the single or dual chamber type is increasing. This webcast concentrates on the aseptic pharmaceutical packaging process challenges that need to be addressed in the final filling process of dual chamber syringes, where both liquid and powdery substances are mixed by the patient immediately prior to injection.
This practice shows clear advantages as it can eliminate preservatives needs while enabling longer shelf lives.
Filling syringes with liquid and powder in separate compartments is a big challenge in various respects. First of all not only sterility must be guaranteed throughout the whole process but also a very high degree of containment due to the high concentrations of the active ingredients contained in the powder. The required containment can only be achieved with complex isolators as opposed to open restricted access barrier systems (oRABS).
Another challenge is the requirement of a highly accurate dosing technology, able to precisely dose these active ingredients in the mg range which is, depending on the material properties, very difficult to achieve. There are also problems when the plungers are inserted into the syringes, because powder deposit on the inner surface of the syringe chamber can lead to leak issues which ca be prevented by pre-compacting the powder before its introduction.
This case study based presentation puts forward solutions to overcome these difficulties and shows best practices on how to integrate an aseptic syringe filling process in a single production line encompassing powder and liquid filling under controlled conditions.
How to effectively manipulate highly potent products in the pharmaceutical
and chemical industry
This live online event will give you the opportunity to gain insight on process innovation, occupational health and safety questions and appropriate technologies available today to overcome the many challenges in high containment manufacturing facilities.
The handling of HPAPIs is a highly complex process and calls for sophisticated equipment and process isolators.
Dec offers comprehensive solutions for R&D teams to production plants.
Topics include:
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Occupational Exposure Bands and Limits (OEB/OEL) and risk management
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Understanding all sources of contamination
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How to achieve OEB 7 levels
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Isolator contained transfer systems and powder transfer into the enclosure
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Process equipment interfaces
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Isolator environment and air filtration systems
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Cleaning - Hygenic design - Avoiding cross-contamination
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Isolator and glove integrity
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Case examples
Cómo unir la tecnología de transporte de polvos al concepto de aisladores para los procesos sólidos y líquidos
WEBINAR IN SPANISH
Recent years have shown steady growth in the manufacture of sterile and highly potent products in the pharmaceutical industry.
Antibiotics for intravenous or intramuscular injection in solid and liquid form for example should be produced under sterile conditions.
Due to increasing legislation and a better awareness of operator exposure risks, containment is a major concern for many industries. The latest regulations clearly indicate that risks must be addressed at their sources and that protection against exposure should be achieved by means other than personal protective equipment (PPE) and should be achieved to the extent possible by control measures through engineering.
The following questions will be treated
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Can different products be produced in the same plant?
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For high potency oral solid products, is the PTS Powder Transfer System applicable? How is cleaning validated?
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When using isolators in the microbiologic laboratories, what suggestions can be given in terms of design and specialization?
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Is it easy to validate the PTS Powder Transfer System along with the process?
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Is an isolator everything that has the name ISOLATOR?
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How to minimize static chrages and segregation during the powder transfer?
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What is the difference between RABs and an isolator?
The increase in toxicity and reactivity of pharmaceutical ingredients and the ever stricter production standards in terms of operator and environment protection as well as quality control have made containment essential and handling materials in non-closed environments is obsolete. The handling of potent or sterile products is usually the bottleneck in the design of a facility leading to complex and expensive processes.
The selection of technologies approved by the authorities is a key factor to the success of a pharmaceutical plant. As a recognized expert in high containment manufacturing equipment and process isolator technology, Dec offers comprehensive solutions for highly toxic, sterile and toxic-sterile materials which can overcome common hurdles. In this webinar we will show you our approach on designing modular manufacturing facilities allowing for quick product changes and generating high productivity.
Topics include
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Operator and plant Safety aspects
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High containment equipment for powder handling up to OEB 7
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Hygienic procedures (CIP/SIP)
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Linking processes; from batch towards semi-continuous manufacturing
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Sterile manufacturing
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Increasing productivity
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Latest trends in patient delivery systems associated to highly automated aseptic filling lines for liquids and powder