Biopharma
Manufacturing
Controlled, aseptic environments
The preparation of media and dosing solutions for upstream processes, as well as buffers for downstream applications, is crucial for ensuring reproducible and effective biopharmaceutical production. The media primarily consists of essential components such as carbohydrates (e.g., glucose), nitrogen sources (e.g., amino acids), lipids (fats), and trace amounts of salts, all of which are vital for the nutritional support necessary for protein synthesis. Typically, these media components are supplied in powder form, which must be dissolved in high-purity Water for Injection (WFI).
To maintain stringent cleanliness standards, the powder must be introduced into preparation tanks for media and buffers in a controlled, aseptic manner, adhering to cleanroom protocols. After preparation, the resulting solutions are transferred into storage tanks, from which they can be distributed to various reactors or vessels. These solutions serve multiple purposes, including culture media, correction media, fed-batch media, and buffers for downstream processing.
The PTS Powder Transfer System® offers an optimal solution for charging powders into media vessels under controlled and aseptic conditions. This innovative system can be sterilized alongside the vessels, ensuring that the entire process adheres to the highest standards of hygiene and safety.
