Continuous Processing System Reaction, Crystallization, Filter Drying
Continuous Processing Technologies
Smart manufacturing with innovative flow chemistry
In an effort to move away from conventional batch production and modernizing the global chemical processing industry,
continuous manufacturing (CM) is the common vision and desire with the potential to increase efficiency, quality and
flexibility in manufacturing.
Dec is one the very few companies able to offer end-to-end CM process solutions. From the incoming raw material handling to the API synthesis and processing of the compounded drug into the final dosage form including injectables and from bench to production scale.
Reactors & Crystallizers
Available in a range of sizes to suit your requirements from laboratory to production scale
Ideal for cooling, evaporative and antisolvent crystallisations
Low shear mixing produces little particle attrition with good control over particle size distribution and morphology
Flexible modes of operation – batch, semi- or fully continuous
Fully automated from single vessel batch or continuous stirred tank reactors to multi-vessel continuous or semi-continuous chained stirred tank reactors. Liquid/Liquid, Solid/Liquid and Gas/Liquid capabilities at pressures up to 25 bar and temperatures up to 200 °C. Improved residence time distribution compared to traditional stirred tanks.
Unique chemistry facilitators for gas to liquid hydrogenency
Liquid liquid, gas liquid and solid liquid reactions and crystallisations acting as a catalyst for crystallisation
Highly efficient heat transfer and mixing capabilities
Excellent crystal size and morphology control
Equipment can be provided with temperature controlled transfer lines to avoid unwanted crystallisations or side reactions. Probe adapters available to suit most PAT
Continuous Filtration & Drying
Modern flow chemistry technology for enhanced efficiency in Fine Chemical, Pharmaceutical and Laboratory processing
Filter dryer systems automatically filter, wash, dry and discharge solids in a continuous manner.
Continuous filtration is available in evaluation, pilot, production scale platforms
Lower footprint - One complete plant replaces a traditional 2 to 3 floor batch production facility.
No mechanical agitation damage or crystal shear
Reliable consistency in cake filtration
Accurate repeatability of washing parameters
Atomization nozzles dispense wash solvent preventing disturbance to the cake
Thinner cake height technology, typically 10 - 30 mm
Improved wash efficiency!
Local HMI or DCS control system allows for safe operation
Integrated alarm systems for automated continuous operation
Very high repeatability and consistency in filtration
Reduced solvent usage, energy and waste
0.1 mm heel! Significantly lower heel – Significantly reducing product loss!
Entry to exit cycle time in minutes… not hours!
Filtration, washing and drying in just a few short runs!
Drying to <1% moisture content achieved within minutes
Typical throughputs of 1 kg per hour to 24 kg per hour of dried product
Drying validated with drying kinetics models
Scalable Continuous Processing Solutions